How Macrophages Regulate Influenza Virus Infection

Grant number: 1184532 | Funding period: 2020 - 2023

Completed

Abstract

Airway immune cells play a protective role during influenza virus infection. We have shown they do this by potently blocking seasonal influenza virus growth, but not the growth of highly pathogenic strains. This may contribute to severe disease. This project will reveal how airway immune cells control the severity of influenza infection. The findings will provide a platform to develop innovative therapeutic strategies to limit the impact of severe influenza virus disease during future pandemics.

Related publications (3)

Caveats of Using Overexpression Approaches to Screen Cellular Host IFITM Proteins for Antiviral Activity

T Meischel, S Fritzlar, F Villalón-Letelier, JM Smith, AG Brooks, PC Reading, SL Londrigan

2023-04-01

Ectopic protein overexpression in immortalised cell lines is a commonly used method to screen host factors for their antiviral act..

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

LI Labzin, KY Chew, K Eschke, X Wang, T Esposito, CJ Stocks, J Rae, R Patrick, H Mostafavi, B Hill, TE Yordanov, CL Holley, S Emming, S Fritzlar, FL Mordant, DP Steinfort, K Subbarao, CM Nefzger, AK Lagendijk, EJ Gordon

2023-04-01

Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease caused by the virus SARS-CoV-2. The SARS-Co..

IFITM proteins that restrict the early stages of respiratory virus infection do not influence late-stage replication

T Meischel, S Fritzlar, F Villalon-Letelier, MB Tessema, AG Brooks, PC Reading, SL Londrigan

2021-10-01

Interferon-induced transmembrane (IFITM) proteins inhibit a broad range of enveloped viruses by blocking entry into host cells. We..

University of Melbourne Researchers

Sarah Londrigan